A recent study on dermatologic effects of the Levonorgestrel IUD was published online in the Journal of the American Academy of Dermatology.
Researchers from the Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, reviewed the US Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) through December 2023 for dermatological adverse events associated with IUDs that release hormones.
They compared users of copper IUDs with users of levonorgestrel IUDs where IUDs were the only suspected cause of acne, alopecia, and hirsutism. The research included 139,348 reports related to Levonorgestrel IUDs (including Kyleena, Liletta, Mirena, and Skyla), and 50,450 reports of copper IUD users ( paragard).
Findings
- In general Levonorgestrel IUD users showed higher odds of reporting acne (odds ratio [OR], 3.21), alopecia (OR, 5.96), and hirsutism (OR, 15.48; all P < .0001) than copper IUD users.
- The Kyleena 19.5 mg levonorgestrel IUD was associated with the highest odds of acne reports (OR, 3.42), followed by the Mirena 52 mg (OR, 3.40) and Skyla 13.5 mg (OR, 2.30) levonorgestrel IUDs (all P < .0001).
- The Mirena IUD was associated with the highest odds of alopecia and hirsutism reports (OR, 6.62 and 17.43, respectively), followed by the Kyleena (ORs, 2.90 and 8.17, respectively) and Skyla (ORs, 2.69 and 1.48, respectively) IUDs (all P < .0001).
Levonorgestrel is a synthetic progestin with androgenic properties that stimulates male characteristics. The use of androgenic compounds increases the risk of acne or sexual hair growth in some women.
The authors of the study concluded “Overall, we identified significant associations between levonorgestrel IUDs and androgenic cutaneous adverse events,” They added, “Counseling before initiation of levonorgestrel IUDs should include information on possible cutaneous adverse effects including acne, alopecia, and hirsutism to guide contraceptive shared decision making.”
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Levonorgestrel IUDs and Skin Side Effects
A recent study on dermatologic effects of the Levonorgestrel IUD was published online in the Journal of the American Academy of Dermatology.
Researchers from the Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, reviewed the US Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) through December 2023 for dermatological adverse events associated with IUDs that release hormones.
They compared users of copper IUDs with users of levonorgestrel IUDs where IUDs were the only suspected cause of acne, alopecia, and hirsutism. The research included 139,348 reports related to Levonorgestrel IUDs (including Kyleena, Liletta, Mirena, and Skyla), and 50,450 reports of copper IUD users ( paragard).
Findings
Levonorgestrel is a synthetic progestin with androgenic properties that stimulates male characteristics. The use of androgenic compounds increases the risk of acne or sexual hair growth in some women.
The authors of the study concluded “Overall, we identified significant associations between levonorgestrel IUDs and androgenic cutaneous adverse events,” They added, “Counseling before initiation of levonorgestrel IUDs should include information on possible cutaneous adverse effects including acne, alopecia, and hirsutism to guide contraceptive shared decision making.”
This entry was posted on Friday, November 15th, 2024 at 8:22 pm and is filed under News & Commentary. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.