New study reveals adverse outcomes from fertility treatments


Children born after Artificial Reproductive Treatments have a greater risk of preterm birth, low birth weight, and extended newborn hospital stay according to a recent study of perinatal outcomes.

Dr Joseph Stanford, MD, from University of Utah, with his colleagues, analyzed the adverse perinatal outcomes associated with Artificial Reproductive Technologies compared to outcomes from spontaneous pregnancies in Florida, Maryland and Utah.

The authors analyzed data from a population-based surveillance system designed by the Centers for Disease Control and Prevention to identify and monitor maternal health and perinatal outcomes.

The study represented 1,022,597 women with live births between 2004 and 2008. Women who received treatment with assisted reproductive technology (ART), intrauterine insemination with ovulation stimulation (IUI), and ovulation stimulation alone (OS) were compared to women who never used fertility treatment and subfertile women who conceived without any treatment.

The authors of the study found that premature birth, very premature birth and low birth weight are six times greater amongst women who undergo ART in the conception cycle compared to all women trying to conceive in the population of the study. Also the newborn hospitals stay of 1 week or longer were three times higher for all ART pregnancies compared with women who never used fertility treatment.

Indeed, it was discussed that much of this risk comes from multiple gestation pregnancies, but even singleton pregnancies achieved by ART had higher risk of complications. Among births of a single baby, and compared with women who never used fertility treatments, women who conceived with ART were three times more likely to experience preterm birth (<37 weeks the due date)

Another finding of the study was that the use of intrauterine insemination (IUI) and ovarian stimulation increased 2 times the risk of prematurity (<34 weeks before the due date) compared with women who never used fertility treatments.

Although preterm birth and low birthweight, were associated with ART, subfertility status itself was significantly associated with very low birthweight.

The authors explained that in contrast, there was a protective association of ‘other various’ fertility treatment on very low birthweight, compared with subfertile women who conceived without treatment. Subfertile couples could achieve pregnancy using fertility treatment protocols, such as Naprotechnology, that are less likely to result in adverse perinatal outcomes that cause long hospital stay for the newborn such as preterm birth or low birthweight.


Leave a Reply

You must be logged in to post a comment.